Current Projects

Examples of Current Research Projects

Neurology:

• Brain Amyloid and Cognition in Normal Elderly
• Natural History of Amyloid Deposition in Adults with Down Syndrome
• Amyloid Deposition, Vascular Disease, and Clinical Progression of Alzheimer’s Disease
• In Vivo Neuroimaging Biomarker Panel for Traumatic Brain Injury
• [¹⁸F]AV-1451 Tau imaging in Control, MCI, and AD subjects

Addiction:

• Psychiatric Molecular Imaging Program (PMIP)

Mood, Sleep, Aging:

• Modulators of Cognitive Transition in Normal Aging
• Testing a Neurobiological Model of Primary Insomnia
• Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
• Effects of CBTI on Functional Anatomy of Sleep in Older Adults with Insomnia

Psychiatry/Psychology:

• Changes in Serotonin Transporter Binding During Interferon-Alpha Treatment: Use of PET
• Does Long-term Lithium Treatment Prevent Amyloid in Elders with Bipolar Disorder?
• Characterization of [¹¹C]flumazenil to Image GABA Transmission in Healthy Adult Subjects
• Neuroimaging Correlates of Psychomotor Slowing in Patients with Diabetes
• Maturation of Striatal Function and Neurophysiology Through Adolescence and Young Adulthood: A Multimodal Imaging PET/fMRI Study

Oncology:

• New Simultaneous Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) Technology for Oncology
• Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
• Imaging Assessments of Cellular Proliferation, Vascularity, and Cellular Metabolites in Glioblastoma Multiforme (GBM)

Drug/Treatment Trials:

• A Phase 3 Extension, Multicenter, Double-Blind, Long Term Safety and Tolerability Trial of Bapineuzumab in Subjects with Alzheimer’s Disease who Participated in Study ELN1152727
• A Phase I/IIA Study of the Safety and Efficacy of Modified Stromal Cells (SB623) in Subjects with Stable Ischemic Stroke
• Effect of Passive Immunization on the Progression of Mild Alzheimer’s Disease: Solanezumab (LLY 2062430) Versus Placebo
• Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study
• DIAN-TU-001: A Phase II/III Randomized, Double-Blind, Placebo-Controlled Multicenter Study of two Potential Disease Modifying Therapies in Individuals at Risk for and with Dominantly Inherited Alzheimer’s Disease
• A Multicenter, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Short-Term Plasma Exchange Followed by Long-Term Plasmapheresis with Infusion of Human Albumin Combined with Intravenous Immunoglobulin in Patients with Mild to Moderate Alzheimer’s Disease

Participation in Multi-Site Imaging Studies:

• Alzheimer’s Disease Neuroimaging Initiative-2 (ADNI-2)
• Dominantly Inherited Alzheimer Initiative (DIAN)
• Multicenter, Multicountry Study to Calibrate Florbetapir (F18) PET Imaging Data to the Centiloid Scale based on [¹¹C]PiB